Xiao-qian Chen | pharmacology | Best Researcher Award

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Prof. Dr. Xiao-qian Chen | pharmacology | Best Researcher Award

Prof. Dr. Xiao-qian Chen, Huazhong University of Science and Technology, China.

Prof. Xiao Qian Chen 🧠 is a leading neurobiology and oncology researcher with over 25 high-impact publications 📚. As a Principal Investigator on 10+ national grants, he has pioneered studies on glioblastoma and neuroglobin. A professor since 2007, he’s received multiple awards 🏅 and holds a patent for neural therapy innovation. His international collaborations 🌍 and mentorship of young scientists 👨‍🔬 make him a driving force in translational brain research.

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Scopus Profile

Orcid Profile

🎓 Early Academic Pursuits

Prof. Dr. Xiao Qian Chen embarked on his academic journey with a Bachelor of Medicine from Shanghai Medical University in 1988. He then pursued a Master’s in Medicine specializing in immunology at Peking Union Medical College and the Chinese Academy of Medical Sciences, graduating in 1997, followed by a Ph.D. in Biology from The Hong Kong University of Science and Technology in 2002. His foundational studies equipped him with a robust interdisciplinary grounding in medicine, immunology, and cutting-edge biological research. 🏛️

💼 Professional Endeavors

Following his Ph.D., Xiao Qian Chen served as an Engineer (1997–1999) at the Laboratory of Molecular Virology, CAS, Beijing. He transitioned to clinical work as a Surgeon (1988–1994) at Xi-Yuan Hospital, blending research with hands-on patient care. His postdoctoral stints included work at Peking University Neuroscience Research Institute (2002–2004) and as a Postdoc/Visiting Scholar (2010–2011) at Emory University’s Pharmacology Department. In academia, he rose from Associate Professor (2004–2007) to Professor from November 2007 at the Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan—where he continues to lead cutting-edge research.

🔬 Contributions and Research Focus On Pharmacology 

Prof. Chen’s research centers on neuroglobin biology, glioblastoma immunology, and neuronal survival under stress. As principal investigator, he has led over ten major projects funded by the National Natural Science Foundation of China, exploring mechanisms of glioma cytotoxicity, astrocyte transformation, and neuroprotection through signaling pathways (e.g., EGFR/PTEN/AKT/PD‑L1). Key themes include neuroglobin’s dual role in oxygen sensing and neuroprotection, and the therapeutic targeting of PD‑L1 and metabolic pathways in brain tumors.

🌍 Impact and Influence

Prof. Chen’s body of work has advanced understanding in both neurobiology and cancer biology. He has identified novel molecular targets such as neuroglobin and PD‑L1, elucidating their roles from neurite outgrowth and hypoxia responses to tumor immunity and chemoradiotherapy resistance. His integrative approach blends molecular experiments, in vivo models, and therapeutic studies, influencing subsequent research in glioblastoma treatment and neuroprotective strategies.

🧠 Research Skills

Prof. Chen’s methodology toolbox is robust and diverse:

  • Cell and molecular biology (protein interactions, gene expression)

  • Animal models (glioblastoma, ischemic stroke, autism, depression)

  • Neurochemistry & signaling assays (EGFR/PTEN/AKT, p38/JNK, autophagy pathways)

  • Immunology techniques (PD‑L1/PD‑1, microglia phenotyping, T‑cell infiltration)

  • Translational therapeutics, especially pharmacological modulation (e.g., Piperlongumine, CD73 inhibitors)

🏅 Awards and Honors

Prof. Chen’s excellence has been recognized through prestigious awards:

  • Second Prize, China Medical Science & Technology Award (2006) — for protective mechanisms in astrocytes during cerebral ischemia.

  • Second Prize, Hubei Science & Technology Progress Award (2019) — for work on Piperlongumamide in cancer treatment.

These accolades affirm the scientific and societal relevance of his discoveries.

🏛️ Legacy and Future Contributions

Prof. Chen’s enduring legacy lies in his cross-disciplinary integration of neuroscience and oncology, particularly in harnessing metabolic and immune modulation for disease intervention. Going forward, his ongoing grants (2022–2025) position him to lead breakthroughs in microglia reprogramming, astrocyte plasticity, and glioblastoma therapeutics. The translational promise of his research holds potential for neuroprotective and immunomodulatory therapies in serious CNS disorders.

Publications Top Notes

  1. 📘 Acta Pharmacologica Sinica (2025)
    Title: CD73 inhibitor AB680 suppresses glioblastoma in mice…
    📅 Year: 2025

  2. 🧠 Theranostics (2025)
    Title: A molecularly distinct cell type in the midbrain regulates intermale aggression…
    📅 Year: 2025

  3. 🧬 Journal of Experimental & Clinical Cancer Research (2023)
    Title: Piperlongumine conquers temozolomide chemoradiotherapy resistance…
    📅 Year: 2023

  4. 🧠 Neuroscience Bulletin (2023)
    Title: Neuroglobin Facilitates Neuronal Oxygenation through Tropic Migration…
    📅 Year: 2023

  5. 🧩 Molecular Neurobiology (2023)
    Title: KMT2E Haploinsufficiency Manifests Autism-Like Behaviors…
    📅 Year: 2023

  6. 🔬 Biochemical and Biophysical Research Communications (2021)
    Title: Rapid tumor recurrence in a novel murine GBM surgical model…
    📅 Year: 2021

  7. 🧪 Clinical and Translational Medicine (2020)
    Title: Mannose synergizes with chemoradiotherapy to cure cancer…
    📅 Year: 2020

  8. 🧠 Frontiers in Oncology (2019)
    Title: The Binding of PD-L1 and Akt Facilitates Glioma Cell Invasion…
    📅 Year: 2019

  9. 📡 Nature Communications (2019)
    Title: Locus coeruleus-CA1 projections are involved in chronic-depressive stress…
    📅 Year: 2019

  10. 🧫 Neurochemical Research (2019)
    Title: Selective 14-3-3γ Upregulation Promotes Beclin-1-LC3-Autophagic Influx…
    📅 Year: 2019

  11. 💊 Frontiers in Pharmacology (2019)
    Title: The prognostic and therapeutic value of PD-L1 in glioma
    📅 Year: 2019

  12. 🧬 Biochimica et Biophysica Acta – Molecular Basis of Disease (2018)
    Title: PD-L1 confers glioblastoma multiforme malignancy via Ras binding…
    📅 Year: 2018

  13. 🧠 Cell Death & Disease (2018)
    Title: Neuroglobin boosts axon regeneration during ischemic reperfusion…
    📅 Year: 2018

 

 

Xin Huang | Medicine | Best Researcher Award

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Prof. Xin Huang | Medicine | Best Researcher Award 

Prof. Xin Huang, Shanghai Jiaotong University School of Medicine Xinhua Hospital, China.

Professor Xin Huang 🧬 is a leading expert in reproductive medicine, specializing in PCOS molecular mechanisms. With over a decade of cutting-edge research, she has published in top journals and received numerous provincial and national awards 🏆. Her work bridges clinical practice and molecular biology, advancing embryo selection and fertility treatments 👩‍⚕️🧪. Professor Huang is also known for her strong interdisciplinary skills, securing multiple competitive research grants and contributing significantly to women’s health globally 🌍💡.

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SCOPUS ID

🎓 Early Academic Pursuits

Prof. Xin Huang earned her Bachelor of Biology from Shandong University (1994–1998), followed by a Master’s in Biochemistry and Molecular Biology at Qingdao Agricultural University (2002–2005), and culminating in a PhD in the same field from Beijing Forestry University (2005–2008). These formative years provided her with a solid foundation in molecular techniques and research methodologies.

💼 Professional Endeavors

Teacher (1998–2002) — Educated high school students at No. 5 Middle School in Zibo, Shandong.

Embryologist (2008–2017) — Served at the Reproductive Medicine Centre, Yuhuangding Hospital, affiliated with Qingdao Medical University in Yantai.

Senior Embryologist & Professor (2017–present) — Leads embryology research and clinical efforts at the Department of Assisted Reproduction, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine.

🔬 Contributions and Research Focus On Medicine 

Since 2008, Professor Huang has focused on reproductive and endocrine disorders, notably polycystic ovary syndrome (PCOS). She pioneered the use of genome-wide microarrays to analyze gene expression in cumulus cells from PCOS patients, identifying key molecular pathways (e.g., Wnt, MAPK, calcium signaling) and biomarkers like LHCGR, TNIK, SOCS3, RUNX2, GPX3, PTX3. Her work extended into lncRNA and miRNA profiling, revealing regulatory molecules such as XLOC_011402 (PWRN2) and miR‑509‑3p that influence steroidogenesis and follicular microenvironment. She also explored follicular fluid metabolomics, using Raman spectroscopy to uncover metabolic signatures predictive of embryo quality and pregnancy outcomes

🌍 Impact and Influence

Professor Huang’s research offers key biomarkers for oocyte and embryo selection in IVF, especially for PCOS populations. Her findings have significantly advanced our understanding of oestradiol regulation, anovulation mechanisms, and the interplay between noncoding RNAs and metabolic pathways — shaping clinical strategies in assisted reproduction.

🧠 Research Skills

  • Embryology: IVF‑ET, ICSI, embryo & oocyte cryopreservation, PGD/PGS, FISH, assisted hatching, time‑lapse monitoring, spindle imaging, sperm viability assays.

  • Molecular Biology: Microarrays (cDNA, miRNA, lncRNA), gene cloning (RACE), vector design, protein assays (SDS‑PAGE, blots), qPCR, BiFC, yeast-two-hybrid, protein expression/purification, reporter assays, transformation techniques.

🏅 Awards and Honors

  • 2nd Prize, Yantai Sci/Tech Award (2014 & 2016)

  • 3rd Prize, Maternal & Child Health Award (2015 & 2017)

  • 2nd Prize, Shandong Medical Sci/Tech Award (2018)

  • 2nd Prize, Shandong Sci/Tech Progress Award (2019)
    These honors reflect sustained excellence in PCOS research and clinical translation.

🏛️ Legacy and Future Contributions

Professor Huang’s integrative approach—merging molecular biomarkers with clinical embryology—has already reshaped IVF strategies for PCOS patients. Her ongoing work in androgen-induced inflammasome activation (NLRP3 in microglia) and clinical metabolomic profiling promises to deepen understanding of PCOS-related comorbidities like depression and refine embryo selection methods. Her legacy is one of innovative translational research, fostering continued breakthroughs in reproductive endocrinology and assisted reproduction.

Publications Top Notes

  1. 📊 Frontiers in Cell and Developmental Biology (2021)
    Title: Raman spectrum of follicular fluid: a potential biomarker for oocyte developmental competence in PCOS
    Authors: Huang X#, Hong L#, Wu Y#, Chen M, Kong P, Ruan J, Teng X, Wei Z*

  2. 🧬 Aging (2020)
    Title: Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in PCOS
    Authors: Huang X#, Wu B#, Chen M#, Hong L, Kong P, Wei Z, Teng X*

  3. 🧪 European Journal of Obstetrics & Gynecology and Reproductive Biology (2020)
    Title: Systematic oxidative stress is not associated with live birth rate in young non-obese PCOS patients undergoing ART
    Authors: Chen M#, Huang X#, Liu Y, Lei S, Wu Y, Chen Z, Hong L, Teng X*

  4. 🧫 BMJ Open (2020)
    Title: Embryo incubation by time-lapse systems vs. conventional incubators in women with diminished ovarian reserve: protocol for RCT
    Authors: Chen M#, Wu Y#, Huang X#, et al.

  5. 🧠 Reproductive Biology and Endocrinology (2018)
    Title: lncRNA (PWRN2)-mediated ceRNA network in oocyte nuclear maturation in PCOS
    Authors: Huang X#, Pan J#, Wu B, Teng X

  6. 🧬 Reproduction (2016)
    Title: miRNA-509-3p promotes estradiol secretion by targeting MAP3K8 in cumulus cells of PCOS patients
    Authors: Huang X*, Liu C, Hao C, et al.

  7. 📚 Journal of Assisted Reproduction and Genetics (2016)
    Title: Aberrant expression of long noncoding RNAs in cumulus cells from PCOS patients
    Authors: Huang X*, Hao C*, Bao H, et al.

  8. 🧬 Reproduction (2013)
    Title: Transcriptional profiles of cumulus cells from MI and MII oocytes in PCOS patients
    Authors: Huang X, Hao C*, Shen X, et al.

  9. 🧬 Reproductive Biology and Endocrinology (2013)
    Title: RUNX2, GPX3, PTX3 gene expression in cumulus cells and embryo competence in PCOS
    Authors: Huang X, Hao C*, Shen X, et al.

  10. 🔥 Journal of Cellular and Molecular Medicine (2019)
    Title: S100‐A9 protein in exosomes from follicular fluid promotes inflammation via NF‐κB in PCOS
    Authors: Li H, Huang X, Chang X, et al.

  11. 🧠 Gynecological Endocrinology (2016)
    Title: GABAA receptor subunit expression in cumulus cells during oocyte maturation
    Authors: Dai H, Hao C*, Huang X, et al.