Xin Huang | Medicine | Best Researcher Award

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Prof. Xin Huang | Medicine | Best Researcher Award 

Prof. Xin Huang, Shanghai Jiaotong University School of Medicine Xinhua Hospital, China.

Professor Xin Huang 🧬 is a leading expert in reproductive medicine, specializing in PCOS molecular mechanisms. With over a decade of cutting-edge research, she has published in top journals and received numerous provincial and national awards 🏆. Her work bridges clinical practice and molecular biology, advancing embryo selection and fertility treatments 👩‍⚕️🧪. Professor Huang is also known for her strong interdisciplinary skills, securing multiple competitive research grants and contributing significantly to women’s health globally 🌍💡.

Profile

SCOPUS ID

🎓 Early Academic Pursuits

Prof. Xin Huang earned her Bachelor of Biology from Shandong University (1994–1998), followed by a Master’s in Biochemistry and Molecular Biology at Qingdao Agricultural University (2002–2005), and culminating in a PhD in the same field from Beijing Forestry University (2005–2008). These formative years provided her with a solid foundation in molecular techniques and research methodologies.

💼 Professional Endeavors

Teacher (1998–2002) — Educated high school students at No. 5 Middle School in Zibo, Shandong.

Embryologist (2008–2017) — Served at the Reproductive Medicine Centre, Yuhuangding Hospital, affiliated with Qingdao Medical University in Yantai.

Senior Embryologist & Professor (2017–present) — Leads embryology research and clinical efforts at the Department of Assisted Reproduction, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine.

🔬 Contributions and Research Focus On Medicine 

Since 2008, Professor Huang has focused on reproductive and endocrine disorders, notably polycystic ovary syndrome (PCOS). She pioneered the use of genome-wide microarrays to analyze gene expression in cumulus cells from PCOS patients, identifying key molecular pathways (e.g., Wnt, MAPK, calcium signaling) and biomarkers like LHCGR, TNIK, SOCS3, RUNX2, GPX3, PTX3. Her work extended into lncRNA and miRNA profiling, revealing regulatory molecules such as XLOC_011402 (PWRN2) and miR‑509‑3p that influence steroidogenesis and follicular microenvironment. She also explored follicular fluid metabolomics, using Raman spectroscopy to uncover metabolic signatures predictive of embryo quality and pregnancy outcomes

🌍 Impact and Influence

Professor Huang’s research offers key biomarkers for oocyte and embryo selection in IVF, especially for PCOS populations. Her findings have significantly advanced our understanding of oestradiol regulation, anovulation mechanisms, and the interplay between noncoding RNAs and metabolic pathways — shaping clinical strategies in assisted reproduction.

🧠 Research Skills

  • Embryology: IVF‑ET, ICSI, embryo & oocyte cryopreservation, PGD/PGS, FISH, assisted hatching, time‑lapse monitoring, spindle imaging, sperm viability assays.

  • Molecular Biology: Microarrays (cDNA, miRNA, lncRNA), gene cloning (RACE), vector design, protein assays (SDS‑PAGE, blots), qPCR, BiFC, yeast-two-hybrid, protein expression/purification, reporter assays, transformation techniques.

🏅 Awards and Honors

  • 2nd Prize, Yantai Sci/Tech Award (2014 & 2016)

  • 3rd Prize, Maternal & Child Health Award (2015 & 2017)

  • 2nd Prize, Shandong Medical Sci/Tech Award (2018)

  • 2nd Prize, Shandong Sci/Tech Progress Award (2019)
    These honors reflect sustained excellence in PCOS research and clinical translation.

🏛️ Legacy and Future Contributions

Professor Huang’s integrative approach—merging molecular biomarkers with clinical embryology—has already reshaped IVF strategies for PCOS patients. Her ongoing work in androgen-induced inflammasome activation (NLRP3 in microglia) and clinical metabolomic profiling promises to deepen understanding of PCOS-related comorbidities like depression and refine embryo selection methods. Her legacy is one of innovative translational research, fostering continued breakthroughs in reproductive endocrinology and assisted reproduction.

Publications Top Notes

  1. 📊 Frontiers in Cell and Developmental Biology (2021)
    Title: Raman spectrum of follicular fluid: a potential biomarker for oocyte developmental competence in PCOS
    Authors: Huang X#, Hong L#, Wu Y#, Chen M, Kong P, Ruan J, Teng X, Wei Z*

  2. 🧬 Aging (2020)
    Title: Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in PCOS
    Authors: Huang X#, Wu B#, Chen M#, Hong L, Kong P, Wei Z, Teng X*

  3. 🧪 European Journal of Obstetrics & Gynecology and Reproductive Biology (2020)
    Title: Systematic oxidative stress is not associated with live birth rate in young non-obese PCOS patients undergoing ART
    Authors: Chen M#, Huang X#, Liu Y, Lei S, Wu Y, Chen Z, Hong L, Teng X*

  4. 🧫 BMJ Open (2020)
    Title: Embryo incubation by time-lapse systems vs. conventional incubators in women with diminished ovarian reserve: protocol for RCT
    Authors: Chen M#, Wu Y#, Huang X#, et al.

  5. 🧠 Reproductive Biology and Endocrinology (2018)
    Title: lncRNA (PWRN2)-mediated ceRNA network in oocyte nuclear maturation in PCOS
    Authors: Huang X#, Pan J#, Wu B, Teng X

  6. 🧬 Reproduction (2016)
    Title: miRNA-509-3p promotes estradiol secretion by targeting MAP3K8 in cumulus cells of PCOS patients
    Authors: Huang X*, Liu C, Hao C, et al.

  7. 📚 Journal of Assisted Reproduction and Genetics (2016)
    Title: Aberrant expression of long noncoding RNAs in cumulus cells from PCOS patients
    Authors: Huang X*, Hao C*, Bao H, et al.

  8. 🧬 Reproduction (2013)
    Title: Transcriptional profiles of cumulus cells from MI and MII oocytes in PCOS patients
    Authors: Huang X, Hao C*, Shen X, et al.

  9. 🧬 Reproductive Biology and Endocrinology (2013)
    Title: RUNX2, GPX3, PTX3 gene expression in cumulus cells and embryo competence in PCOS
    Authors: Huang X, Hao C*, Shen X, et al.

  10. 🔥 Journal of Cellular and Molecular Medicine (2019)
    Title: S100‐A9 protein in exosomes from follicular fluid promotes inflammation via NF‐κB in PCOS
    Authors: Li H, Huang X, Chang X, et al.

  11. 🧠 Gynecological Endocrinology (2016)
    Title: GABAA receptor subunit expression in cumulus cells during oocyte maturation
    Authors: Dai H, Hao C*, Huang X, et al.

 

Lingzhi Zhong | Medicine | Best Researcher Award

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Dr. Lingzhi Zhong | Medicine | Best Researcher Award 

Dr. Lingzhi Zhong PLA General Hospital, China.

Dr. Lingzhi Zhong is an Assistant Research Fellow and Lecturer at the PLA General Hospital 🏥. She holds a Ph.D. in Pathology and Physiology from Jilin University 🎓. Her research specializes in tissue repair and regenerative medicine 🧬. With over ten peer-reviewed publications, several patents, and editorial roles, she has made remarkable strides in wound healing innovations 💡. Dr. Zhong is also a member of the Microcirculation Committee and continues to drive impactful biomedical research with passion and precision 🔬✨.

🌟 Professional Profile

Orcid Profile

🎓 Early Academic Pursuits

Lingzhi Zhong began her academic journey with a Ph.D. in Pathology and Physiology from Jilin University School of Basic Medicine. During her formative years, she cultivated a strong foundation in medical sciences, with a growing interest in tissue repair and regenerative medicine. Her rigorous academic training laid the groundwork for a prolific research career that would later evolve into impactful scientific contributions.

💼 Professional Endeavors

Dr. Zhong currently serves as an Assistant Research Fellow and Lecturer at the Department of Basic Medicine, PLA General Hospital. With over a decade of research experience, she is actively involved in the scientific community, both as a lecturer and investigator. Her professional trajectory also includes editorial roles, contributing as a board member and associate editor for esteemed academic publications. Her academic service underscores her dedication to both teaching and research leadership.

🔬 Contributions and Research Focus On Medicine 

Dr. Zhong’s research centers around wound healing, tissue regeneration, and anti-scarring innovations. One of her notable breakthroughs includes the reprogramming of fibroblasts into endothelial cells using forskolin, a discovery funded by the Youth Project of the National Natural Science Foundation of China. She has also explored the potential of arsenic compounds in inhibiting scar formation—an unprecedented approach in wound repair research. Her multi-faceted innovations bridge chemistry, biology, and medicine.

🌍 Impact and Influence

Her work has made a tangible impact on regenerative medicine, advancing strategies for scar reduction and chronic wound healing. The development of composite dressings and chitosan-based therapeutics reflects her commitment to clinical translation and improved patient outcomes. She has co-authored over ten SCI-indexed publications, each contributing to a better understanding of biological healing processes and therapeutic design.

🏆 Awards and Honors

Dr. Zhong has earned recognition for her pioneering research in regenerative medicine and wound care. Her nomination for the Best Researcher Award underlines her innovative edge and dedication to biomedical science. Her editorial appointments and participation in professional societies like the Microcirculation Committee of the Society of Integrated Traditional Chinese and Western Medicine further reinforce her respected standing in the scientific community.

📚 Books, Patents, and Innovation

Her contributions extend beyond journal articles. Dr. Zhong is currently co-authoring a book titled “Progress in Life Sciences”. She also holds three patents in advanced biomedical technologies:

  1. Composite dressing for skin healing

  2. Chemical induction of dermal fibroblasts

  3. Chitosan-taurine microbeads for scar reduction

These innovations demonstrate her translational research impact, turning lab discoveries into therapeutic applications.

🚀 Legacy and Future Contributions

Lingzhi Zhong is at the forefront of translational regenerative medicine. Her work continues to inspire new methods for scar-free healing, and she remains dedicated to developing novel bioactive delivery systems. With continued research, editorial leadership, and interdisciplinary collaboration, Dr. Zhong is poised to make lasting contributions to science and human health.

📚Publications Top Notes

  1. 🧴 Forskolin-loaded carboxymethyl chitosan and silk nanofiber hydrogels composite scaffolds improve skin regeneration
    International Journal of Biological Macromolecules, 2025

  2. 🧬 Chitosan-taurine nanoparticles cross-linked carboxymethyl chitosan hydrogels facilitate both acute and chronic diabetic wound healing
    International Journal of Biological Macromolecules, 2024

  3. 🧠 Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects
    Stem Cell Research & Therapy, 2022

  4. 🐷 Characterization of the Skin Bacteriome and Histology Changes in Diabetic Pigs
    The International Journal of Lower Extremity Wounds, 2022

  5. 🌿 Promotive effects of four herbal medicine ARCC on wound healing in mice and human
    Health Science Reports, 2022

  6. 🔬 A New Target of the Four-Herb Chinese Medicine for Wound Repair Promoted by Mitochondrial Metabolism Using Protein Acetylation Analysis
    Medical Science Monitor, 2022

  7. 🔥 Macrophage Related Chronic Inflammation in Non-Healing Wounds
    Frontiers in Immunology, 2021

  8. 🧫 Biological approaches for hypertrophic scars
    International Wound Journal, 2020

  9. 🩹 Chitosan/LiCl composite scaffolds promote skin regeneration in full-thickness loss
    Science China Life Sciences, 2020

  10. 🧪 Sustained release of inhibitor from bionic scaffolds for wound healing and functional regeneration
    Biomaterials Science, 2020

  11. 💧 Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives
    Stem Cells International, 2019

  12. 🕸️ Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors To Improve Skin Regeneration
    ACS Applied Bio Materials, 2019

  13. 🚫 Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through NFE2L2 and Smad2/3
    Journal of Cellular Physiology, 2019

  14. 🧪 Comparative Proteomic Analysis of the Effect of the Four-Herb Chinese Medicine ANBP on Promoting Mouse Skin Wound Healing
    The International Journal of Lower Extremity Wounds, 2017

  15. 🧠 Arsenic Trioxide Activate Transcription of Heme Oxygenase-1 via NFE2L2
    International Journal of Medical Sciences, 2015

  16. 🦴 Heme oxygenase-1 silencing increases sensitivity of osteosarcoma MG63 cells to arsenic trioxide
    Molecular and Cellular Biochemistry, 2014