Prof. Zheng Guo | Pharmacology | Best Researcher Award

Prof. Zheng Guo, Second Hospital of Shanxi Medical University, China.

Prof. Zheng Guo 🎓, a renowned anesthesiologist and cardiovascular researcher, holds an M.B. from Shanxi Medical College and a Ph.D. from the University of Leeds. He has served as President of Shanxi Medical University and currently leads its Anesthesiology Department. His research focuses on myocardial ischemia, pain, and the autonomic nervous system 🫀🧠. With multiple NSFC grants and publications in top-tier journals, Prof. Guo is a trailblazer in medical science and an inspiration to future researchers 🔬📚.

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🎓 Early Academic Pursuits

Prof. Zheng Guo began his academic journey with an M.B. from Shanxi Medical College in Taiyuan, China (1978–1983), laying a strong foundation in clinical medicine. Driven by a passion for scientific inquiry, he pursued a Ph.D. at the University of Leeds, UK (1988–1991), where he conducted pioneering research under the mentorship of Professor C.S. Goodchild. His early exposure to both clinical and translational research positioned him for a career at the intersection of medicine and science.

🏥 Professional Endeavors

Prof. Guo has had an illustrious career spanning decades at Shanxi Medical University. He served as President (2000–2009) and earlier as Acting President (1998–2000), steering academic growth and institutional reform. Since 1994, he has chaired the Departments of Anesthesiology at The Second Hospital of Shanxi Medical University and has been a Professor of Anesthesiology since 1997. His enduring commitment to teaching, leadership, and clinical excellence continues to inspire the next generation of medical professionals.

🔬 Contributions and Research Focus On Pharmacology 

Prof. Guo’s research centers on critical physiological mechanisms underlying myocardial ischemia/reperfusion injury, diabetes, stress responses, and the autonomic and sensory nervous systems, especially in relation to pain. His studies have elucidated how neurogenic and neuropeptidergic pathways affect cardiac health, with implications for anesthetic practices and cardiovascular therapies.

🌍 Impact and Influence

Prof. Guo’s work has significantly influenced both basic and clinical sciences in cardiology and anesthesiology. Through his dual leadership in research and education, he has elevated the global reputation of Shanxi Medical University. His mentorship has shaped numerous clinicians and researchers, contributing to the academic growth of the field in China and abroad.

🧠 Research Skills

Prof. Guo possesses comprehensive expertise in experimental cardiovascular pharmacology, pain modeling, neurophysiological assays, and animal model validation. His command over complex research methodologies and interdisciplinary collaboration has enabled groundbreaking discoveries in pain and cardiac injury mechanisms.

🏅 Awards and Honors

Throughout his career, Prof. Guo has been recognized for his excellence in research and education. Although specific honors are not listed here, his leadership roles and consistent funding from prestigious bodies like the National Natural Science Foundation of China (NSFC) stand as testaments to his scientific and professional distinction.

Publications Top Notes

📄 Comprehensive validation of a custom three-point bending system for standardized diabetic fracture models in rats
👨‍🔬 Guo Q., Wang W., Guo Z.
🧬 Journal of Orthopaedic Surgery and Research, 2025
🔧🐀 Focus: Diabetic fracture models, biomechanics

🧪 Morphine timing-dependent modulation of TRPV1 phosphorylation correlates with differential morphine effects on myocardial ischemia/reperfusion injury
🧑‍🔬 Wang X., Li X., Jiang B., Wang T., Guo Z.
💉 European Journal of Pharmacology, 2024
❤️‍🔥💊 Focus: Morphine effects on heart injury and TRPV1 receptor modulation

💔 Epidural administration of large dose of opioid μ receptor agonist may impair cardiac functions and myocardial viability via desensitizing transient receptor potential vanilloid 1
🧪 Ma X., Guo Z., Li M., Wang T., Sun T.
🫀 Toxicology and Applied Pharmacology, 2024
🧠💔 Focus: Cardiac effects of high-dose opioids and TRPV1 receptor desensitization

🫀 Antagonism of N/OFQ attenuates externalization of β1-adrenergic receptor and ventricular arrhythmias in acute myocardial ischemia rat model
🔬 Han Y., Xiong C., Zhang L., Yang G., Guo Z.
💉 European Journal of Pharmacology, 2022
⚡❤️ Focus: Arrhythmia prevention through N/OFQ antagonism

🕒 Impact of timing of morphine treatment on infarct size in experimental animal model of acute myocardial ischemia and reperfusion
🧑‍🔬 Lei Y., Li X., Guo Z.
🫁 European Journal of Pharmacology, 2022
⏱️🫀 Focus: Morphine timing and myocardial infarct size