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π Early Academic Pursuits
Dr. Biaoru Li began his academic journey in Shanghai Second Medical University, earning an MD in Medicine and Pediatrics (1978β1983). His passion for molecular sciences led him to pursue an MS in Hepatic Necrosis and Hepatic Regeneration (1986β1989), followed by a Ph.D. in Molecular Biology and Virology, where his work on TIL and Gene Therapy spanned institutions in China and the University of Florida, USA. Demonstrating foresight into the evolving landscape of computational biology, Dr. Li later obtained an MS in Bioinformatics (2000β2002), focusing on DM-domain proteins in Drosophila melanogaster.
πΌ Professional Endeavors
Dr. Li currently serves as Principal Research Scientist at the Children’s Hospital of Georgia (CHOG) and is a Tenured Faculty member at the Medical College of Georgia. His past roles include clinical bioinformatics specialist positions at top U.S. institutions such as Case Western Reserve University, Stanford-affiliated Artemis Health, and the Baylor Medical Centerβaffiliated Mary Crowley Cancer Center. He has also held key academic and leadership positions, steadily climbing the ranks from Assistant Professor to Senior Faculty.
π¬ Contributions and Research Focus On GeneticsΒ
Dr. Li’s work lies at the nexus of clinical immunology, bioinformatics, and personalized medicine. He pioneered research in tumor-infiltrating lymphocytes (TILs), single-cell RNA sequencing, and machine learning for cancer therapy. His contributions also extend to developing genomic diagnostics, particularly for sickle cell disease and solid tumor treatment using AI-based immunotherapies.
π Impact and Influence
Dr. Liβs innovations have left a global mark, including a UN-recognized contribution in single-cell genomic diagnosis for sustainable development in 2023. His work was featured in Science Magazine (2004), highlighting breakthroughs in nuclear localization signals. Multiple Research Incentive Awards (2014β2022) at CHOG underscore his sustained excellence. His research outputs have impacted oncology, genomics, and bioinformatics, influencing policy and clinical protocols.
π§ Research Skills
Dr. Li is proficient in genome editing, RNA-seq analysis, AI modeling, and bioinformatics pipeline development. He brings hands-on experience with clinical molecular diagnostics, viral vector systems, and CRISPR-based gene editing. His ability to integrate wet lab research with computational modeling sets him apart as a truly interdisciplinary scientist.
π
Awards and Honors
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π UN Award (2023): Recognized as a global expert in sustainable development using single-cell genomics and AI.
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π₯ Eight-time CHOG Research Incentive Awardee (2014β2022)
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𧬠Patents in cancer stem cell isolation and genomic degeneration detection
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π News Feature in Science Magazine (2004) for pioneering SRY gene research
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π Certified in Clinical Bioinformatics, Human Clinical Trials, and FDA Ethics
ποΈ Legacy and Future Contributions
Dr. Li is proficient in genome editing, RNA-seq analysis, AI modeling, and bioinformatics pipeline development. He brings hands-on experience with clinical molecular diagnostics, viral vector systems, and CRISPR-based gene editing. His ability to integrate wet lab research with computational modeling sets him apart as a truly interdisciplinary scientist.
Publications Top Notes
π¬ Molecular Biology & Protein Interactions
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𧬠How insulin binds: The B-chain α-helix contacts the L1 β-helix of the insulin receptor
π Journal of Molecular Biology, 100 citations, ποΈ 2004
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𧬠Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues
π Biochemistry, 55 citations, ποΈ 2004
π§ Genetics & Sex Determination
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π» Human sex reversal due to impaired nuclear localization of SRY: a clinical correlation
π Journal of Biological Chemistry, 71 citations, ποΈ 2001
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π§ SRY and architectural gene regulation: the kinetic stability of a bent protein-DNA complex can regulate its transcriptional potency
π Molecular Endocrinology, 43 citations, ποΈ 2001
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𧬠SRY-directed DNA bending and human sex reversal…
π Journal of Molecular Biology, 41 citations, ποΈ 2006
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β§οΈ Sex-specific gene regulation: the doublesex DM motif is a bipartite DNA-binding domain
π Journal of Biological Chemistry, 50 citations, ποΈ 2002
π©Έ Hematology & Sickle Cell Disease
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π©Έ MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease
π Experimental Hematology, 62 citations, ποΈ 2019
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π§ͺ Dimethyl fumarate increases fetal hemoglobin…
π JCI Insight, 51 citations, ποΈ 2017
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𧬠NRF2 mediates Ξ³-globin gene regulation…
π Haematologica, 42 citations, ποΈ 2017
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𧬠Monomethylfumarate induces Ξ³-globin expression…
π Investigative Ophthalmology & Visual Science, 36 citations, ποΈ 2014
𧫠Leukemia & Oncology
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𧫠P15INK4B gene methylation and expression…
π Leukemia, 54 citations, ποΈ 2001
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𧬠Telomerase activity in preleukemia and acute myelogenous leukemia
π Leukemia & Lymphoma, 46 citations, ποΈ 2000
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π§ͺ Suppression of Telomerase Activity… in AML Cells in Vivo
π Clinical Cancer Research, 38 citations, ποΈ 2000
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𧫠SCF, IL-1Ξ², IL-1ra and GM-CSF in bone marrow and serum…
π Cytokine, 54 citations, ποΈ 2000
𧬠Cancer Genetics & Genomics
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𧬠DNA alterations in human aberrant crypt foci and colon cancers
π Cancer Research, 43 citations, ποΈ 2003