Tzong-Shyuan Lee | Biomedicine | Best Researcher Award

Prof. Tzong-Shyuan Lee | Biomedicine | Best Researcher Award 

National Taiwan University | Taiwan

Dr. Tzong-Shyuan Lee, DVM, Ph.D., is a distinguished Professor in the Graduate Institute and Department of Physiology at the College of Medicine, National Taiwan University, Taipei, Taiwan. His extensive research focuses on the pathophysiology of age-related diseases, particularly cardiovascular and neurodegenerative disorders. Dr. Lee’s investigations integrate clinical reagents, nutritional compounds, and traditional herbal medicines through comprehensive in vitro and in vivo approaches to explore therapeutic interventions. His pioneering work has identified several molecular targets and elucidated key mechanistic pathways involved in cardiovascular dysfunction, fatty liver disease, chronic kidney disease, and Alzheimer’s disease. With an impressive scholarly record of 144 publications, 7,843 citations across 6,667 documents, and an h-index of 50, Dr. Lee’s contributions have significantly advanced biomedical research on vascular biology and aging. He has also demonstrated outstanding editorial leadership as Associate Editor for Frontiers in Physiology and Journal of Physiological Investigator, and as Academic Editor for Scientifica (Vascular Medicine Section), Exploration of Endocrine and Metabolic Diseases, and Aging Advances. His expertise is further reflected in his role as an invited reviewer for more than 185 scientific journals. Beyond his research and editorial activities, Dr. Lee has provided exemplary academic leadership as Director of the Department and Graduate Institute of Physiology and as Chairman of the Institutional Animal Care and Use Committee at National Taiwan University. His sustained research excellence, coupled with his leadership and service, underscores his status as a leading figure in cardiovascular and aging-related disease research.

Profile: Scopus | Orcid

Featured Publications 

Lee, T.-S., et al. (2025). Genetic deletion of TRPM8 channels restores microvascular function and mitigates chronic kidney disease progression. Free Radical Biology and Medicine.

Lee, T.-S., et al. (2025). Bromelain enhances nitric oxide bioavailability: Bradykinin's link to TRPV1/Ca²⁺/AMPK/autophagy signaling. Biomedicine and Pharmacotherapy.

Lee, T.-S., et al. (2025). Rac1 signaling mediates the protection of apigenin against hepatic lipid accumulation and insulin resistance. Biomedicine and Pharmacotherapy.

Lee, T.-S., et al. (2025). Bromelain prevents Alzheimer's disease progression by suppressing oxidative stress and upregulating apolipoprotein A1 in 5x familial Alzheimer's disease transgenic mice. Journal of Agriculture and Food Research.

Lee, T.-S., et al. (2025). HMGB1 regulates adipocyte lipolysis via caveolin-1 signaling: Implications for metabolic and cardiovascular diseases. International Journal of Molecular Sciences.

Dehua Chang | Regenerative Medicine Research | Best Researcher Award

Dr. Dehua Chang | Regenerative Medicine Research | Best Researcher Award 

University of Tokyo Hospital | Japan

Dr. Dehua Chang, M.D., Ph.D., is a highly accomplished researcher and clinician specializing in cardiovascular surgery and regenerative medicine. He currently serves as a Specially Appointed Associate Professor at the Department of Cell Therapy in Regenerative Medicine, University of Tokyo Hospital, and holds multiple visiting professorships at leading institutions, including Fudan University, Shanghai Jiao Tong University, and Zhengzhou University. With a prolific academic and professional background spanning Japan, China, Europe, and the United States, Dr. Chang has made significant contributions to stem cell therapy, tissue engineering, and cardiac regeneration. His work has been widely recognized, with 29 published documents, 838 citations, and an h-index of 15, reflecting his influential research impact in the field. He has developed several innovative patents related to cell sheet technologies and mesenchymal stem cell applications, advancing translational approaches in regenerative medicine. As a member of the Japanese Society for Regenerative Medicine and a reviewer for leading journals such as Stem Cell Research & Therapy, Regenerative Therapy, and Acta Biomaterialia, Dr. Chang contributes extensively to scientific peer review and editorial excellence. His clinical and research expertise encompasses cell-based therapies for ischemic heart disease, heart failure, osteoarthritis, and vascular disorders, with a focus on the industrialization and clinical application of stem cell sheet products. Fluent in Chinese, English, and Japanese, Dr. Chang bridges international collaboration, academic leadership, and innovation in regenerative cardiovascular medicine, positioning him as a global expert in translational medical research and clinical cell therapy.

Profile: Scopus 

Featured Publications 

Wang, Y.-H., Liu, T.-T., Guo, Y.-P., Zhu, S.-J., Liao, Z.-M., Song, J.-M., Zhu, X.-M., Liang, J.-L., Nasser, M. I., Liu, N.-B., Chang, D.-H., Zhu, P., & Yao, B.* (2025). Integrating melt electrospinning writing and microfluidics to engineer a human cardiac microenvironment for high-fidelity drug screening. Bioactive Materials.

Zhu, S., Xuan, J., Shentu, Y., Kida, K., Kobayashi, M., Wang, W., Ono, M., & Chang, D.* (2024). Effect of chitin-architected spatiotemporal three-dimensional culture microenvironments on human umbilical cord-derived mesenchymal stem cells. Bioactive Materials