Prof. Tzong-Shyuan Lee | Biomedicine | Best Researcher Award
National Taiwan University | Taiwan
Dr. Tzong-Shyuan Lee, DVM, Ph.D., is a distinguished Professor in the Graduate Institute and Department of Physiology at the College of Medicine, National Taiwan University, Taipei, Taiwan. His extensive research focuses on the pathophysiology of age-related diseases, particularly cardiovascular and neurodegenerative disorders. Dr. Lee’s investigations integrate clinical reagents, nutritional compounds, and traditional herbal medicines through comprehensive in vitro and in vivo approaches to explore therapeutic interventions. His pioneering work has identified several molecular targets and elucidated key mechanistic pathways involved in cardiovascular dysfunction, fatty liver disease, chronic kidney disease, and Alzheimer’s disease. With an impressive scholarly record of 144 publications, 7,843 citations across 6,667 documents, and an h-index of 50, Dr. Lee’s contributions have significantly advanced biomedical research on vascular biology and aging. He has also demonstrated outstanding editorial leadership as Associate Editor for Frontiers in Physiology and Journal of Physiological Investigator, and as Academic Editor for Scientifica (Vascular Medicine Section), Exploration of Endocrine and Metabolic Diseases, and Aging Advances. His expertise is further reflected in his role as an invited reviewer for more than 185 scientific journals. Beyond his research and editorial activities, Dr. Lee has provided exemplary academic leadership as Director of the Department and Graduate Institute of Physiology and as Chairman of the Institutional Animal Care and Use Committee at National Taiwan University. His sustained research excellence, coupled with his leadership and service, underscores his status as a leading figure in cardiovascular and aging-related disease research.
Featured Publications
Lee, T.-S., et al. (2025). Genetic deletion of TRPM8 channels restores microvascular function and mitigates chronic kidney disease progression. Free Radical Biology and Medicine.
Lee, T.-S., et al. (2025). Bromelain enhances nitric oxide bioavailability: Bradykinin's link to TRPV1/Ca²⁺/AMPK/autophagy signaling. Biomedicine and Pharmacotherapy.
Lee, T.-S., et al. (2025). Rac1 signaling mediates the protection of apigenin against hepatic lipid accumulation and insulin resistance. Biomedicine and Pharmacotherapy.
Lee, T.-S., et al. (2025). Bromelain prevents Alzheimer's disease progression by suppressing oxidative stress and upregulating apolipoprotein A1 in 5x familial Alzheimer's disease transgenic mice. Journal of Agriculture and Food Research.
Lee, T.-S., et al. (2025). HMGB1 regulates adipocyte lipolysis via caveolin-1 signaling: Implications for metabolic and cardiovascular diseases. International Journal of Molecular Sciences.