Dehua Chang | Regenerative Medicine Research | Best Researcher Award

Dr. Dehua Chang | Regenerative Medicine Research | Best Researcher Awardย 

University of Tokyo Hospital | Japan

Dr. Dehua Chang, M.D., Ph.D., is a highly accomplished researcher and clinician specializing in cardiovascular surgery and regenerative medicine. He currently serves as a Specially Appointed Associate Professor at the Department of Cell Therapy in Regenerative Medicine, University of Tokyo Hospital, and holds multiple visiting professorships at leading institutions, including Fudan University, Shanghai Jiao Tong University, and Zhengzhou University. With a prolific academic and professional background spanning Japan, China, Europe, and the United States, Dr. Chang has made significant contributions to stem cell therapy, tissue engineering, and cardiac regeneration. His work has been widely recognized, with 29 published documents, 838 citations, and an h-index of 15, reflecting his influential research impact in the field. He has developed several innovative patents related to cell sheet technologies and mesenchymal stem cell applications, advancing translational approaches in regenerative medicine. As a member of the Japanese Society for Regenerative Medicine and a reviewer for leading journals such as Stem Cell Research & Therapy, Regenerative Therapy, and Acta Biomaterialia, Dr. Chang contributes extensively to scientific peer review and editorial excellence. His clinical and research expertise encompasses cell-based therapies for ischemic heart disease, heart failure, osteoarthritis, and vascular disorders, with a focus on the industrialization and clinical application of stem cell sheet products. Fluent in Chinese, English, and Japanese, Dr. Chang bridges international collaboration, academic leadership, and innovation in regenerative cardiovascular medicine, positioning him as a global expert in translational medical research and clinical cell therapy.

Profile: Scopusย 

Featured Publicationsย 

Wang, Y.-H., Liu, T.-T., Guo, Y.-P., Zhu, S.-J., Liao, Z.-M., Song, J.-M., Zhu, X.-M., Liang, J.-L., Nasser, M. I., Liu, N.-B., Chang, D.-H., Zhu, P., & Yao, B.* (2025). Integrating melt electrospinning writing and microfluidics to engineer a human cardiac microenvironment for high-fidelity drug screening. Bioactive Materials.

Zhu, S., Xuan, J., Shentu, Y., Kida, K., Kobayashi, M., Wang, W., Ono, M., & Chang, D.* (2024). Effect of chitin-architected spatiotemporal three-dimensional culture microenvironments on human umbilical cord-derived mesenchymal stem cells. Bioactive Materials

Chuan-Mu Chen | Biology | Excellence in Research Award

Prof. Dr. Chuan-Mu Chen | Biology | Excellence in Research Award

Prof. Dr. Chuan-Mu Chen, National Chung Hsin University,Taiwan.

๐Ÿ”ฌ Prof. Chuan-Mu Chen is the Vice President of National Chung Hsing University (NCHU), Taiwan, and a Chair Professor in Molecular Embryology and Biotechnology. With a Ph.D. in Genetic Engineering, he has made exceptional contributions to animal biotechnology, stem cell research, and transgenic animals. He holds numerous national and international honors ๐Ÿ… and plays key roles in Taiwanโ€™s scientific advancement. His innovative research continues to shape the future of life sciences and biotechnology ๐Ÿงฌ.

๐ŸŒŸ Professional Profile

๐ŸŽ“ Early Academic Pursuits

Dr. Chuan-Mu Chen began his academic journey with a Bachelor of Science in Animal Science from National Taiwan University (1987โ€“1991). Driven by a passion for molecular life sciences, he pursued a Ph.D. in Genetic Engineering at the same institution (1991โ€“1995), where he laid a strong foundation in molecular embryology and biotechnology. His early training emphasized interdisciplinary research in genetics, animal science, and embryonic development.

๐Ÿ’ผ Professional Endeavors

Dr. Chenโ€™s illustrious career spans academia, research, and administrative leadership. Currently the Vice President and Chair Professor at National Chung Hsing University (NCHU), Taiwan, he also holds a chair professorship at National Quemoy University. His prior roles include Dean of the College of Life Sciences, Director of Research & Development, and Consultant to the Ministry of Education and other major institutions. His international exposure includes research appointments in the USA and UK, strengthening global collaborations.

๐Ÿ”ฌ Contributions and Research Focus On Biologyย 

Dr. Chenโ€™s research specializes in molecular embryology, animal biotechnology, stem cell biology, transgenic and cloning technologies, tumor biology, and human-disease animal models. His pioneering work on amniotic fluid mesenchymal stem cells and DNA methylation microarray has advanced the understanding of gene expression and regenerative medicine. He has significantly contributed to developing functional peptides and novel biomedical applications.

๐ŸŒ Impact and Influence

Recognized globally, Dr. Chenโ€™s innovations have led to impactful collaborations, patents, and commercialization of biotech advancements. He has served as a General Director of the iEGG and Animal Biotechnology Research Center and contributed to the growth of Taiwanโ€™s life science research ecosystem. His guidance has mentored a new generation of researchers and expanded Taiwanโ€™s academic footprint internationally.

๐Ÿ† Awards and Honors

Dr. Chen has received over 45 prestigious awards, including the Outstanding Research Award from the Ministry of Science and Technology (twice), the TECO Award in Biomedical Science, the National Innovation Awards, and the President Agricultural Award. He was named a Lifetime Distinguished Professor at NCHU and has won multiple international honors from Japan, the U.S., and Europe recognizing his excellence in research and invention. ๐Ÿ†

๐Ÿ“ˆAcademic Citationsย 

Dr. Chenโ€™s prolific output includes numerous publications in high-impact journals, reflecting his authority in molecular and developmental biology. His work is widely cited, establishing him as a leader in translational medicine and biotechnological innovation.

๐Ÿš€ Legacy and Future Contributions

With a legacy marked by groundbreaking discoveries and impactful teaching, Dr. Chen continues to drive innovation in molecular biosciences. His leadership at NCHU and commitment to mentoring ensures the nurturing of future scientists. As biotechnology and regenerative medicine evolve, Dr. Chen is poised to remain a central figure, contributing transformative solutions to global health and agricultural challenges. ๐Ÿš€

๐Ÿ“šPublications Top Notes

๐Ÿ“Š Methylation-specific oligonucleotide microarray
Genome Research | 405 citations | ๐Ÿ—“ 2002
๐Ÿ”ฌ DNA methylation profiling for high-throughput epigenetic analysis

๐Ÿงฌ Dissecting complex epigenetic alterations in breast cancer
Cancer Research | 325 citations | ๐Ÿ—“ 2001
๐ŸŽ—๏ธ Breast cancer, CpG island microarrays

๐Ÿง  Psoriasis independently associated with hyperleptinemia
Archives of Dermatology | 263 citations | ๐Ÿ—“ 2008
โš•๏ธ Skin disease, metabolic syndrome link

๐ŸŽฏ Methylation microarray in late-stage ovarian carcinomas
Clinical Cancer Research | 248 citations | ๐Ÿ—“ 2002
๐Ÿงซ Epigenetics, ovarian cancer prognosis

๐ŸŒฌ๏ธ Hypoxia-preconditioned mesenchymal stem cells in fibrosis
Stem Cell Research & Therapy | 243 citations | ๐Ÿ—“ 2015
๐Ÿ’‰ Stem cell therapy, lung fibrosis

๐Ÿงช Genotyping of hepatitis D virus by RFLP
The Lancet | 205 citations | ๐Ÿ—“ 1995
๐Ÿฆ  Virus genetics, disease outcome

๐Ÿผ VP1 protein oral vaccine via transgenic mice milk
Vaccine | 176 citations | ๐Ÿ—“ 2008
๐Ÿ’‰ Transgenic vaccine against EV71

๐Ÿ– Spread of hepatitis E virus in pigs
Journal of Medical Virology | 165 citations | ๐Ÿ—“ 2002
๐Ÿ” Zoonosis, viral surveillance

๐Ÿงซ Hypermucoviscosity in Klebsiella pneumoniae infections
BMC Microbiology | 150 citations | ๐Ÿ—“ 2011
๐Ÿงฌ Bacterial virulence

๐Ÿงฌ Methylation target array for CpG hypermethylation
The American Journal of Pathology | 137 citations | ๐Ÿ—“ 2003
๐Ÿงช High-throughput epigenetic analysis

๐Ÿท Swine hepatitis E virus: clinical implications
Journal of Medical Virology | 132 citations | ๐Ÿ—“ 2000
๐Ÿงผ Public health & veterinary virology

๐Ÿฅ› Bovine lactoferrin inhibits lung cancer growth
Journal of Dairy Science | 125 citations | ๐Ÿ—“ 2013
๐Ÿงซ Nutraceuticals, anti-cancer research

๐Ÿง  miR-196a ameliorates Huntingtonโ€™s disease phenotypes
AJHG | 124 citations | ๐Ÿ—“ 2013
๐Ÿงฌ Gene therapy, neurodegeneration

๐Ÿฆ  Lactoferrin against E. coli infection
Biometals | 124 citations | ๐Ÿ—“ 2011
๐Ÿงซ Antimicrobial proteins

๐Ÿงฌ CpG island microarray for gene silencing detection
Cancer Research | 120 citations | ๐Ÿ—“ 2002
๐Ÿงช Epigenetics & cancer gene regulation

๐Ÿฉบ Plasma osteopontin in psoriasis and cardiovascular risk
JAAD | 118 citations | ๐Ÿ—“ 2009
โค๏ธ Inflammatory marker in comorbidity

๐Ÿงฌ CpG island microarrays in DNA methylation
The Journal of Nutrition | 115 citations | ๐Ÿ—“ 2002
๐Ÿ“Š Nutrigenomics & methylation studies

๐Ÿฅ› Kefir peptides prevent obesity via lipid modulation
Mol. Nutrition & Food Research | 110 citations | ๐Ÿ—“ 2018
๐Ÿถ Functional foods in metabolic health

๐Ÿฆด Kefir-fermented milk & bone health in osteoporosis
PLOS ONE | 108 citations | ๐Ÿ—“ 2015
๐Ÿฆด Bone density enhancement via probiotics

๐Ÿ’‘ Transmission of hepatitis D virus to spouses
Hepatology | Citations not listed | ๐Ÿ—“ Year not listed
๐Ÿฆ  Viral genome sequencing, epidemiology